Ophthalmology and Otology Research Service
JOINN’s Ophthalmology and Otology Research Platform supported by a dedicated team of over 35 experienced researchers and 500 square meters of state-of-the-art facilities, equipped with advanced diagnostic and research technologies for ophthalmology and otology. The platform offers a comprehensive array of animal models for ocular and auditory diseases, ranging from rodents to non-human primates，and supports global clients across navigate every stage of the non-clinical drug and medical device development, including in vivo efficacy study and Good Laboratory Practice (GLP) toxicology studies.
Services
Pharmacodynamic evaluation
Safety evaluation
Pharmacokinetic evaluation
Disease Animal Models
Disease
Animal Models
Dry eye
Scopolamine and controlled environment（rat）
Spontaneous (dog)
Corneal and Conjunctival Diseases
Corneal neovascularization (rabbit)
Scratching of corneal epithelial / endothelial cells (rabbit)
Corneal scar (rabbit)
Pterygium (rabbit)
Ocular Inflammation
Allergic conjunctivitis (guinea
pig)
Uveitis (rat, rabbit)
Cataract
Sodium selenite subcutaneous injection (rat)
Spontaneous (NHP)
Glaucoma
Laser induced ocular hypertension (NHP)
Glucocorticoid induced ocular hypertension(rat)
Magnetic beads anterior chamber injection(rat)
Retinal/Choroidal
Diseases
Retinal neovascularization
(rabbit)
Choroidal neovascularization
(mouse, rat, NHP)
Retinal vein occlusion (rat, NHP)
Diabetic retinopathy (rat)
Retinal degeneration（sodium iodate，blue light，MNU, NMDA）(mouse, rat, rabbit, NHP)
Optic Nerve Injury
Ischemia/reperfusion (rat)
Mechanical injury (rat)
ND4 gene mutation(mouse)
Opa-1 gene mutation (mouse)
Myopia
Form deprivation (guinea pig)
Others
Spontaneous ocular diseases in aged NHP
Ophthalmic and Otologic Examinations
Slit-lamp microscopy
Direct and indirect ophthalmoscopy
Intraocular pressure
Fundus photography
Fundus fluorescein angiography
Optical coherence tomography (OCT)
OCT angiography
Flash electroretinogram (ERG)
Multifocal electroretinogram
Flash visual evoked potential (VEP)
Corneal confocal microscopy
Three-dimensional anterior segment analyzer (OCULUS Pentacam)
Ophthalmic A/B ultrasound
Ultrasound biomicroscopy
Refractive index examination
Axial length examination
Pupillometer examination
Small animal visual detection and analysis
Visual behavioral examination
Hearing test (ABR, DPOAE)
Animal Species
Rodents: mice, rats, guinea pigs
Non-rodents: rabbits, dogs, mini pigs, non-human primates, etc.
Service Advantages
Rich experience in the evaluation and filing of ophthalmic drugs and devices
Customized pharmacodynamic evaluation services
Standardized and comprehensive ocular administration and examination techniques
Precise ocular tissue sampling and analysis techniques
Complete pathological examination
Comprehensive project management system
Advanced information systems, instruments, and barrier facilities
Service Experience
Over 1200 preclinical ocular and otology studies, conducted at our laboratory. Facilitating the successful translation of numerous novel drugs and devices from bench to clinic.
The first gene therapy developed in China using AAV technology to be granted Investigational New Drug status by the U.S. FDA
The first ocular drug from China approved by the U.S. FDA to enter Phase 3 clinical trials.
The first gene therapy for Leber’s Congenital Amaurosis (LCA) in China to receive IND approval from the CDE
The first gene therapy in China using the suprachoroidal route to be granted IND approval by the CDE
