Safety Pharmacology
JOINN has been engaged in new drug development and safety pharmacology evaluation for 30 years. Over the years, JOINN has established a stable team of safety pharmacology evaluation with strong technical skills and rich experience, capable of providing and conducting comprehensive safety pharmacology evaluation services. All experimental designs comply with international standards for preclinical safety evaluation of new drugs (ICH S7A, S7B), NMPA regulations, and guidelines for the use and management of laboratory animals.
Services
Cardiovascular System Tests
Unrestrained Conscious Animals (Dogs, Miniature Pigs, Non-human Primates)
Electrocardiogram and Hemodynamic Tests in Anesthetized Animals (Dogs, Non-human Primates)
Langendorff Isolated Heart Function Test
Patch Clamp: hERG
Respiratory System Tests
Unrestrained Conscious Animals (Dogs, Non-human Primates): Respiratory Rate, Tidal Volume, Minute Ventilation
Rodents (Whole Body Plethysmography Mode): Respiratory Rate, Tidal Volume, Minute Ventilation
Central Nervous System Evaluation
Irwin’s Test, Functional Observation Battery (FOB) (Mice, Rats, Dogs, Cynomolgus Monkeys)
Spontaneous Activity in Mice and Rats
Rotarod Test
Grip Strength Test
Gastrointestinal Pharmacology Tests
Detection of Gastric Acid Secretion, pH, and Bile Secretion in Rats
Detection of Gastrointestinal Motility in Mice
Urinary System and Renal Function Tests
Detection of Renal Function in Rats
