Metabolic disease models
|
Indication |
Model |
Species |
|
Obesity |
Diet-induced Obesity (DIO) |
mice |
|
cynomolgus monkey |
||
|
Ob/Ob mice |
Ob/Ob mice |
|
|
Type 1 diabetes mellitus |
STZ-induced T1DM |
rat, mice |
|
cynomolgus monkey |
||
|
Type 2 diabetes mellitus |
db/db mice |
db/db mice |
|
ZDF rat |
ZDF rat |
|
|
STZ + HFD-induced T2DM |
mice |
|
|
Spontaneous T2DM |
cynomolgus monkey |
|
|
Euglycaemic clamp |
Beagle dog |
|
|
Hyperlipidemia/ Hypercholesterolemia |
HFHC diet |
ApoE mice |
|
Golden hamster |
||
|
cynomolgus monkey |
||
|
Atherosclerosis |
HFHC diet |
ApoE mice |
|
HFHC diet + mechanical vessel injury |
rabbit |
|
|
cynomolgus monkey |
||
|
Hyperuricemia |
Spontaneous hyperuricemia |
UOX mice |
|
Induction of hyperuricemia |
SD rat |
