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SSE: 603127
HKEX: 06127

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Non-Clinical Safety Assessment

DIABETES COMPLICATIONS

Severe long-term complications of diabetes include: cardiovascular diseases, chronic kidney failure (also known as diabetic nephropathy), neuropathy, and microvascular complications. Among these, microvascular complications can lead to impaired wound healing. JOINN's diabetes complication models include:

  1. 1. Diabetic neuropathic pain
  2. 2. Diabetic nephropathy (DN)
  3. 3. Delayed wound healing in diabetes

 Indication

 Model

 Species

 Diabetic nephropathy

 STZ + nephrectomy + high salt load

 rat, mice

 Delayed diabetic wound healing

 STZ-induced T1DM + skin excision

 rat

 T2DM + skin excision

 db/db

 ZDF rat

 Diabetic neuralgia

 STZ-induced T1DM

 mice

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