Bioanalysis and Pharmacokinetics Studies
JOINN possesses a variety of analytical platforms, including chromatography, ligand binding, PCR, and isotope labeling, which can meet the needs for preclinical and clinical bioanalysis of small molecule compounds, biotechnology products, cell and gene therapy products, and biomarkers. The company can also provide a comprehensive ADME pharmacokinetics evaluation system that complies with domestic and international standards. This system can systematically assess drug absorption, distribution, metabolism, and excretion, supporting customers' full - process development needs from early drug discovery to registration. Additionally, JOINN offers services such as immunoassay, gene function validation, and biomarker detection, providing full - process solutions for cutting - edge products like immunotherapy and cell therapy.
Bioanalytical Methods
Chemical drugs: HPLC, LC - MS/MS, ICP/MS, Online - SPE - MS/MS
Proteins and peptides: ELISA, EIA, RIA, ECL, LC - MS/MS, Western blot
Cell and gene therapy products: qPCR, dPCR, FACS, isotope labeling, IHC, ISH
Bioactivity assays: Blood coagulation time, enzyme - catalyzed reactions, etc.
Analytical Instruments and Equipment
LC - MS/MS (liquid chromatography - mass spectrometry)
Sciex Triple QuadTM 7500（3）
Sciex Triple QuadTM 6500+（5）
Sciex Triple QuadTM 6500（5）
Sciex Triple QuadTM 5500（10）
API4000（4）
Shimadzu 8050 LC-MS/MS（4）
Water TQD（1）
Water TQS（4）
Agilent ICP-MS（2）
Sciex Triple TOF（2）
Bio - macromolecule drug analysis
Enzyme Immuno Assay Analyzer（5）
MSD（3）
Q-PCR（3）
DD-PCR（1）
Automated chemiluminescent immunoassay analyzer (3)
Sample storage and management
-80℃ Refrigerators (29)
Other refrigerators (24)
Sample dilution and preparation
Hamilton Microlab STAR
Large - scale automated liquid handling workstation
In vitro pharmacokinetics
Plasma protein bindingMicrosomal/lysosomal/plasma stability and metabolite identification
Metabolic phenotype
Transporters
Drug - drug interactions (enzyme induction, enzyme inhibition, etc.)
In vivo ADME
Animal species
Rodents: Mice, hamsters, rats, guinea pigs, etc.
Non - rodents: Rabbits, dogs, mini - pigs, non - human primates, etc.
Juvenile animals
Route of administration
Intravenous, oral, transdermal, ophthalmic, inhalation, in situ injection, etc.
Research content
Pharmacokinetics
Tissue distribution and excretion
Metabolite identification
Bioequivalence (BE), bioavailability
Service Advantages
Strong Analytical Technical Capabilities
Method development and validation: Rich experience in method development for peptides, ADCs, bispecific antibodies, small - molecule oligonucleotides, and special formulations of chemical drugs
Data processing and statistical analysis: BE equivalence, PK parameters, WinNonlin data statistical analysis
Standardized bioanalytical system and laboratory management
Watson™ LIMS, complete audit trail, unified standard operating procedures and report formats, traceable data and backup system
