In vivo biological evaluation platform
Through continuous innovation in model development, JOINN has successfully established a comprehensive library of over one hundred specialized disease animal models, covering a broad range of therapeutic areas including oncology, central and peripheral nervous system disorders, cardiovascular and metabolic diseases, autoimmune disorders, gastrointestinal and hematological diseases, reproductive and endocrine disorders, as well as dermatological and infectious diseases. Leveraging the dual-track service platform—comprising both GLP-certified systems and flexible non-GLP research modules—JOINN provides customized, end-to-end research solutions ranging from early-stage screening to IND submission. This ensures that candidate drugs undergo three levels of validation prior to clinical entry: confirmation of pharmacological efficacy, elucidation of mechanism of action, and comprehensive safety assessment.
In vivo models
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Metabolic disease models |
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Obesity |
Diet-induced Obesity (DIO)（mice/cynomolgus monkey） |
ob/ob mice (ob/ob mice) |
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Type 1 diabetes mellitus |
STZ-induced T1DM（rat, mice, NHP) |
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Type 2 diabetes mellitus |
db/db rice |
ZDF rats |
STZ+HFD induced T2DM |
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Spontaneous T2DM（NHP） |
Euglycaemic clamp（Beagle dog） |
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Hyperlipidemia/ Hypercholesterolemia |
HFHC diet（ApoE mice、Golden hamster、NHP） |
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Atherosclerosis |
HFHC diet（ApoE mice） |
HFHC diet + mechanical vessel injury（rabbit，NHP） |
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Hyperuricemia |
Spontaneous hyperuricemia Induction of Hyperuricemia（UOX mice） |
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Diabetes complications |
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Diabetic nephropathy |
STZ + nephrectomy + high salt load （rat，mice） |
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Delayed diabetic wound healing |
STZ-induced T1DM +skin excision（rat） |
T2DM + skin excision（db/db mice、ZDF rat） |
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Diabetic neuralgia |
STZ-induced T1DM（mice） |
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Endocrine Disease |
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Osteoporosis |
Ovariectomy-Induced Osteoporosis（rat， NHP） |
hRANKL-induced Osteoporosis (RANKL rat) |
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Digestive Disorders |
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Acute gastric ulcer |
Water stress / Histamine induction / Ethanol induction / Pentagastrin induction / NSAID induction / Pylorus ligation (rat) |
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Chronic gastric ulcer |
Acetic acid cauterization (rat) |
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Acute and chronic liver injury/fibrosis |
CCl4 Induction |
TAA Induction |
Bile duct ligation |
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Hepatic fibrosis/ decompensated cirrhosis |
CCl4 + HFD + ethanol (rat) |
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Nonalcoholic fatty liver disease (NASH) |
MCD-induced NASH (mice) |
CDAA + HFD-induced NASH (mice) |
STZ + HFD-induced NASH (newborn mice) |
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CCl4 + HFD (rat) |
GAN/ALMN diet-induced NASH（mice, ob/ob mice） |
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HFHC diet-induced NASH（NHP） |
High Fructose Diet Induction (Golden hamster) |
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Blood Disorders |
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Coagulation disorders |
Artery thrombosis (rat, rabbit, dog） |
Deep venous thrombosis（rat, rabbit） |
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Arteriovenous (AV) shunts（rat, rabbit） |
Disseminated intravascular coagulation, DIC（mice） |
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Pulmonary embolism（rat） |
Hemophilia（F8 KO mice） |
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Granulocyte/ thrombocytopenia |
CD41antibody-induced Immune thrombocyte penia，ITP（rat） |
Chemotherapy / Radiotherapy – induced granulocytopenia（mice，monkey） |
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Anemia |
Anemia of renal disease（rat） |
Chemotherapy-induced anemia（rat，mice，monkey） |
Aplastic anemia（mice） |
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Vasculitis |
Lauric acid-induced（rat） |
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Lymphocyte reflux disorder |
Surgically induced（mice） |
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Reproductive System Disease |
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Asthenospermia |
Busulfan-induced Asthenospermia（mice） |
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Primary ovarian insufficiency |
VCD-induced Primary ovarian insufficiency （rat） |
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Assisted Reproductive Technology |
Controlled Ovarian Hyperstimulation |
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Pelvic Inflammatory Disease |
Phenol-induced, PID (rat) |
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Urologic Diseases |
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Acute kidney injury |
Unilateral Renal Ischemia-Reperfusion (rat) |
Cisplatin-induced AKI (rat, mice) |
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Chronic kidney disease/renal fibrosis |
5/6 nephrectomy (rat, NHP) |
Gentamicin-induced CKD (rat) |
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Adenine-induced CKD (rat) |
Unilateral ureteral obstruction (UUO)-induced CKD (rat) |
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Skin |
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Wound healing |
Skin excision (rat, mice, swine) |
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Burn |
Burn (swine) |
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Inflammation & Autoimmune Disease |
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Rheumatoid arthritis |
CFA induced arthritis （rat，mice） |
Collagen induced arthritis |
Spontaneous（Tg197mice、Tg1006 mice） |
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Systemic lupus erythematosus (SLE) model |
Spontaneous（MRL/Lpr mice） |
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GvHD |
PBMC transplant（NOG/NPG mice） |
Allogeneic hematopoietic stem cell transplantation（NHP） |
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Ulcerative colitis |
DNCB-induced colitis model |
DSS colitis model（mice） |
TNBS-induced model（mice，rat） |
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EAE |
MOG35-55-induced EAE（B6 mice） |
PLP139-151-induced EAE（SJL mice） |
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Psoriasis |
Imiquimod induced psoriasis model（mice） |
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Atopic dermatitis models |
M903-induced AD（mice） |
DNCB-induced AD（mice） |
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Sepsis |
LPS-induced sepsis（mice） |
Cecal ligation and puncture (CLP)-induced sepsis（rat） |
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Infectious Disease |
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Influenza |
Influenza challenge model（ferret） |
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HBV infection |
HBV-Tg Mice |
AAV-HBV infection |
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HBV infection（humanized liver chimeric mice） |
HepG2 2215 cell line |
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