Pharmacology

Through years of accumulation, JOINN has established a complete anti-tumor drug screening model, which can evaluate the efficacy of biomacromolecule and chemical small molecule drugs, and has carried out the efficacy evaluation of a number of Her2, CD20, VEGF, EGFR, CD52, CD19 and other targeted biomacromolecule drugs. Pharmacodynamic evaluation of many small molecule drugs such as kinase inhibitors and new dosage forms of paclitaxel has also been carried out.The established efficacy evaluation platform is as follows:

In vitro Studies

Cell proliferation inhibition screening test: 100+ cell lines

Screening test of anti-tumor drugs by hollow fiber method

Chorioallantoic membrane (CAM) test of chicken embryo

In vivo Studies

Subcutaneous xenograft model of human cells: lung cancer, liver cancer, colon cancer, breast cancer, ovarian cancer, prostate cancer, lymphoma, glioma, gastric cancer, pancreatic cancer, cervical cancer, skin cancer, leukemia, etc.

Tumor models of intravenous inoculation of human cells: lymphoma and leukemia

Human cell orthotopic transplantation tumor models: lung cancer, liver cancer, glioma, breast cancer

Murine cell tumor model

Transgenic animal tumor model for efficacy evaluation of anti-PD-1 antibody

Animal tumor models of humanized immune system