Cellular and Gene Therapy

JOINN has over 20 years of experience in non-clinical assessment of cell therapy and gene therapy drugs, and has established comprehensive evaluation capacity of cell therapy and gene therapy products on the basis of animal test platform for preclinical safety assessment.Currently, a number of related products have been approved worldwide, including stem cell therapy drugs, CAR T cells, oncolytic viruses, and so on.

As the most complete non-clinical assessment platform in China, JOINN participated in the first batch of pre-clinical evaluation of stem cell and CAR T cell therapy products in China. JOINN has participated in the preclinical study of the only TCR T cell and neoantigen T cell therapy products that have received registered clinical approval in China. In an era of endless innovation, including CAR NK, a variety of specially modified CAR T and universal CAR T products. The advantage of JOINN lies in its unique and comprehensive cell therapy drug evaluation platform, professional and strong expert and technical team, in-depth interpretation of domestic and foreign regulations. It can intervene early in the process of cell therapy drug development, and provide comprehensive support services including regulatory consultation, effectiveness research, safety evaluation, clinical trials, pharmacovigilance, etc.

Technology Platform

We have a wealth of industry leading molecular biology, cell biology, analysis, imaging equipment. Fully confront the complexity of cell therapy and gene therapy products.

● Quantitative PCR

Cell and gene therapy products in vivo molecular level study of distribution, retention, homing and other behavior of the most important technology

● Flow cytometry

Cell therapy products in vivo cell level study of retention, distribution, cell phenotype analysis and other key technologies

● Ultra sensitive analysis of the product expressed in vivo

The level of expressed products in vivo is often low, and highly sensitive immunoassay techniques are very important for the evaluation of expressed products

● Imaging techniques

Imaging studies based on PET-MRI and NIR provide important information for the distribution and homing of cell therapy products

Services

In vivo research and analysis of cell therapy and gene therapy products involves a number of disciplines:

● Viral vector gene therapy products

● Non-viral vector gene therapy products

● Oncolytic viruses

● Stem cell therapy products

● In vitro stimulation of immune cell products

● CAR T and other genetically modified cells